Role of gamma interferon in the pathogenesis of bacteremic pneumococcal pneumonia.
نویسندگان
چکیده
Gamma interferon (IFN-gamma) concentrations in blood, but not in lungs, rose significantly at 24 to 48 h after murine pulmonary infection with virulent pneumococci. In contrast, infection with avirulent pneumococcal strains produced minimal rises in serum IFN-gamma concentrations. Compared with that of immunocompetent mice, mortality was appreciably increased after pulmonary infection of IFN-gamma gene knockout mice, suggesting a protective role for IFN-gamma in host response to pneumococcal disease.
منابع مشابه
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ورودعنوان ژورنال:
- Infection and immunity
دوره 65 7 شماره
صفحات -
تاریخ انتشار 1997